Scientific Program

Conference Series Ltd invites all the participants across the globe to attend 3rd International Conference on Hematology & Blood Disorders Atlanta, USA.

Day 2 :

OMICS International Hematology 2015 International Conference Keynote Speaker Knox Van Dyke  photo
Biography:

Knox Van Dyke completed his PhD in Biochemistry in the Nobel Prize Department of Dr. Edward A Doisy at Saint Louis University in 1966. He began to study about malaria at West Virginia University Medical School and developed the first high throughput screening system for antimalarial drugs identifying mefloquine and halofantrine which were commercially developed. He and Associate Professor Zuguang Ye recognized bisbenzylisoquinolines synergize with chloroquine causing resistance reversal to chloroquine as demonstrated in Aotus monkeys creating a malarial cure. He edited and published 7 books for CRC Press, Boca Raton Florida and has written over 300 manuscripts.

Abstract:

Shreck and Bauerle in 1991 demonstrated that antioxidants and substances that inhibit the nf-kappa b transcription factor inhibit the replication of the human immunodeficiency virus in vitro (EMBO J 1991). Van Dyke and Owens studied the effect of anti-inflammatory steroids, and antioxidants-- vitamins C and E, N-acetyl cysteine and feline vitamins/ minerals on 6 cats (infected in the wild) with feline immunodeficiency virus (FIV) or feline leukemia (FL) or both. The serum from each cat was assayed before and after combinational treatment via SNAP ELISA for both FIV and FL. Positive virus assay is confirmed via blue color. After the cats were treated with the combination, they would be tested weekly for a period of several months. Depo-Medrol was the steroid used requiring injection every other week but the antioxidants were placed daily in the food or given by mouth. The animals were confined to prevent reinfection. After 3- 4 months, the animals produced a negative test for FIV/FL. Negative tests (PCR) were confirmed at Upjohn Pharmaceuticals and the cats gained weight and were healthy. An untreated but infected (control) cat died . When a similar treatment was used by a very ill 10 year human HIV survivor, he gained weight started feeling better after several months. Blood assay for HIV revealed undetectable levels at a year. All treatments for HIV have a latent untreatable state. Currently,we have found a substance which will activate the latent state with little toxicity raising the possibility of a cure with multiple combined treatments.

Keynote Forum

Robert Michael Davidson

The American Institute of Stress, USA

Keynote: The ascorbate radical as a universal biological group transfer catalyst in inflamed tissue

Time : 10:30-11:00

OMICS International Hematology 2015 International Conference Keynote Speaker Robert Michael Davidson  photo
Biography:

Robert Michael Davidson completed his PhD in Pharmaceutical Chemistry at the age of 26 from UCSF, NSF postdoctoral fellowship at the National Bureau of Standards, Center for Analytical Chemistry, MD degree at St Louis University School of Medicine, Nuclear Medicine residency at Baylor College of Medicine, Houston, Texas, and Internal Medicine residency in Phoenix, Arizona. He was Associate Medical Director for DuPont Pharma’s Radiopharmaceutical Division 1990-1992. He has published more than 30 papers in peer-reviewed journals. He is a Fellow of The American Institute of Stress (2012-present) and recently retired from complementary/alternative/integrative internal medicine practice in East Texas (USA).rnrn

Abstract:

We propose that the Ascorbate radical and its 2-O-substituted-L-ascorbate radicals provide lifelong modulators of redox kinetics and universal group transfer catalysts in inflamed tissue during the Sanarelli-Shwartzman Phenomenon, DIC syndrome, cancer, sepsis, neurodevelopment, and atherosclerosis. We propose that the Ascorbate radical is capable of catalyzing biological group transfer of sulfuryl, phosphoryl, nitrosyl, acyl, and glycosyl moieties in a biosemiotically- and biophysically-concerted, quantum coherent manner which is well-suited to proceed urgently under inflammatory conditions of low pH and high oxidative stress. We propose that the Ascorbate radical provides the biophysical basis for the high degree of temporal and spatial regiospecificity of the multitude of posttranslational modifications of HSPGs, acid mucopolysaccharides, which play essential roles in the inflammatory state, including recycling, proofreading, and editing of biomacromolecules. Human diseases may be characterized by derangements of transcriptional, translational, and posttranslational modifications of biomacromolecules. The reported inhibition by copper and ascorbate of plasmin, tPA, aryl sulfatases, and many serine proteases is mechanistically-generalizable, and plays an essential role in the modulation of redox kinetics, in vivo, throughout our lifetimes. Under our hypothesis, the Ascorbate radical sits at the nexus of biological group transfers and redox kinetics, with profound epigenetic, supramolecular, and biophysically-pleiotropic consequences. Importantly, its concentration is renewable and can be modulated orthomolecularly and biophysically. We will explore the detailed supramolecular basis and clinical implications, in a series of papers to follow.

Break: Networking & Refreshments Break 11:00-11:20 @ Foyer