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Ojo Omotola Toyin

University of Ibadan, Nigeria

Title: Acute Megakaryoblastic Leukaemia (FAB M7)

Biography

Biography: Ojo Omotola Toyin

Abstract

Acute megakaryoblastic leukaemia (AML, M7) is a rare type of Acute myeloid leukemia (AML) evolving from primitive megakaryoblasts. It accounts for 1.2% of newly diagnosed AML by Eas tern Cooperative Oncology Group (ECOG) trials between 1984 and 1997. Patients may present with a broad variety of symptoms including low-grade fever, easy bruising, and life-threatening conditions. We report a rare case of AML,M7 in a 19-year-old lady who presented with weakness and fatigue. She was diagnosed as a case of AML M-7 on the basis of peripheral blood finding, bone marrow examination report, radiological findings and immuno phenotyping. Review of peripheral blood film showed immature mononuclear cells with cytoplasmic blebs. There were giant forms of platelet on the film. The bone marrow imprint showed increased immature mononuclear cells with abundant basophilic cytoplasm containing vacuoles and hyperchromatic and pleomorphic nuclei, some have cytoplasmic blebs, constituting over 90% of nucleated cells. Overall picture was in keeping with Acute Myeloblastic Leukaemia most likely Acute Megakaryoblastic Leukaemia (AML M7) which was confirmed by immunophenotyping of peripheral blood with positivity for CD 33, CD41 and CD 61. X-rays of tibia and fibula showed osteosclerosis in our patient which is in line with  osteosclerotic  lesions described in few case reports.To our knowledge, this is the first such case in the literature in our environment. The lesson here is never to say never and that proficiency in morphologic diagnosis remain the window through which uncommon diagnosis can be confirmed by molecular technology particularly in resource-limited environment.