Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series : World's leading Event Organizer

Back

Patrick Van Dreden

Sorbonne Universities, France

Title: Defining the impact of immunomodulators and thrombin generation profile in patients with active multiple myeloma: The ROADMAP study.

Biography

Biography: Patrick Van Dreden

Abstract

Backround: Multiple myeloma (MM) and the associated immunomodulatory (IMiD)treatments are associated with risk of vascular complications. Thrombin generation (TG) assessment reflects the equilibrium between procoagulant and anticoagulant activities in the plasma.

Aim: We conducted a multicenter study to explore the relationship between stages of MM and alterations of thrombin generation profile.

Methods: Patients with MM (n=129) were recruited from July 2014 to December 2016 and stratified to the following groups: 44 newly diagnosed treatment-naïve patients (ND), 33 patients receiving IMiDs (IM), 45 in complete remission (CR) and 7 patients in partial remission on IMiDs (PR/IM). Patients on anticoagulant treatment were excluded from the study. The control group (CG) consisted of 30 healthy age and sex-matched individuals. Samples of platelet-poor plasma (PPP) were assessed for thrombin generation (TG) with the TF 5pM PPP-Reagent® on Calibrated Automated Thrombogram (Stago, France). The upper and lower normal limits (LNL and UNL) were calculated by the mean±2 SD.

Results: Patients with ongoing MM (ND, IM, PR/IM) had significantly lower Peak, ETP and MRI as compared to the CG. In contrast, patients in CR had Peak, ETP, MRI values similar to the CG. Patients with PR had lower ETP and MRI values as compared to the CR group (Table 1). In ND 8% had TG >UNL and 20% had TGUNL and 57% had TGUNL and 33% had TGUNL and 14% had TG

Conclusion: Patients with active MM showed attenuated TG which was enhanced in the presence of IMiD treatment. Complete remission was associated with normalization of TG. The unexpected decrease of TG in patients with active MM and its normalization when the disease is in a remission might indicate that this test reflects vascular aggression which is followed by release of thrombomodulin, heparin cofactor II, sEPCR and TFPI.