Jay S Raval
University of North Carolina, USA
Title: Acquired thrombotic thrombocytopenic purpura: Disease pathogenesis, laboratory monitoring and current treatment strategies
Biography
Biography: Jay S Raval
Abstract
Acquired thrombotic thrombocytopenic purpura (TTP) is a rare and potentially fatal disease that is due to platelet-von Willebrand Factor microthrombi in the circulation. The discovery of ADAMTS13, its role in cleaving unusually-large von Willebrand Factor multimers, and the detection of autoantibodies/inhibitors directed against this essential enzyme have reinforced the important roles of plasma exchange and immunosuppression in patients with this critical illness. TTP disease pathogenesis, routine and novel laboratory markers for diagnosing and following patients with TTP, and up-to-date treatment strategies will be covered in this lecture