Hematology & Blood Disorders

Biography

Biography: Robert Michael Davidson

Abstract

In consideration of the “universal nonspecific mesenchymal reaction”, also referred to as the Sanarelli-Shwartzman phenomenon, we raise the question: how can the SULTs (sulfotransferases) and PAPS molecules assemble and perform the multitude of sulfation reactions required to produce all of the many posttranslational modifications of mucopolysaccharides and proteoglycans? It seems improbable to us that SULTs, which are typically highly-specific in their stereochemical requirements, would have sufficient enzymatic “promiscuity” to permit the proper positioning of the sulfuryl groups for each of many distinct locations in the 3-dimensional structure of heparan sulfate proteoglycans (HSPGs) and proteoglycans which typically populate the “mesenchyme”. We have proposed a novel chiral, paramagnetic orthomolecule as a potential candidate universal “sulfation factor”, which would potentially circumvent the high metabolic energy requirement of the SULTs/PAPS system, thru use of ELF EM energy sources. We postulate that such a factor may involve miRNAs, molecular mimicry, water-mediated allostery, and highly-stereotyped, nonspecific chemistry of the type that might have taken place on a primordial/prebiotic planet where, at least initially, only smaller and simpler orthomolecules existed. We propose that enantionmeric enrichment and chiral induction was enabled by the effect of ELF EM fields on nanoassociates of water which formed adjacent to hydrophilic surfaces in various mixtures of solutes. Hexagonal symmetry, helices of variable pitch and helix angle, and fractality are predicted to arise from an ice-like hexameric, cyclic radical-cationic cluster of water, as the basis for the “fractal dimension”, within “fractones”, which have been identified in the brain, heart, gut, and bone marrow.