C Cameron Yin
The University of Texas, USA
Title: Immunoglobulin is expressed in acute myeloid leukemia and affects myeloblasts survival
Biography
Biography: C Cameron Yin
Abstract
We studied immunoglobulin gamma heavy chain (IgG) expression in acute myeloid leukemia (AML) and found that IgG was expressed at a high frequency and level in AML cell lines and primary myeloblasts but not in monocytes or neutrophils from patients with non-hematopoietic neoplasms or healthy controls. We further detected IgG VHDJH transcripts in AML cell lines and sorted primary myeloblasts, confirming that IgG expression was indeed produced by AML cells. AML-IgG gene rearrangements showed evidence of somatic hyper mutation and restricted (AML cell lines) or biased (primary myeloblasts) V usage. Anti-human IgG reduced cell viability and induced apoptosis in AML cell lines. Our findings suggest that AML-IgG may play a role in leukemogenesis and AML progression. AML-IgG may serve as a useful molecular marker for monitoring minimal residual disease or designing target therapy.