Sayeedul Hasan Arif
Jawaharlal Nehru Medical College, India
Title: Single donor versus pooled random donor platelet concentrates: A review of literature
Biography
Biography: Sayeedul Hasan Arif
Abstract
Both platelet concentrates (PC) obtained from 6-7 Buffy coat of whole blood or single donor platelets (SDP) obtained by aphaeresis are indicated to treat hemorrhage secondary to thrombocytopenia which includes Dengue, Malaria, ITP, TTP, DIC, Septicemia etc. Dengue and Malaria are very important indications in developing countries like India. It is also used to provide prophylaxis from hemorrhage in patients with bone marrow suppression. Currently platelet transfusion therapy is limited due to several reasons, including the consequences of alloimmunization in chronically transfused patients and septic reactions caused by bacterial contamination. There is lot of discussion and debate about which platelet product should be used; many transfusion medicine services favor the primary use of PC, whereas others favor SDP. This review will discuss five areas that should be considered when there is a debate between use of SDP or PC: Infectious complications, transfusion reaction rate, leuko-depletion, reduction of transfusion frequency in patients with bone marrow aplasia and alloimmunization associated with their use and prevention. Various authors believe that SDP offers main advantages over PC for most of these issues. However, taken the issue of high cost with SDP, a PC should be considered wherever possible in developing countries like India, taking into account risk benefit ratio.