Shahtaj Khan
Hayatabad Medical Complex hospital, Pakistan
Title: Childhood leukemias in Khyber Pakhtunkhwa and Afghanistan children, visiting Hayatabad Medical Complex Hospital
Biography
Biography: Shahtaj Khan
Abstract
Objective: The aim of the present study is to evaluate the frequency of childhood leukemias in the children from different districts of Khyber Pakhtunkhwa (KP) and Afghanistan presenting to Hayatabad Medical Complex Hospital, Peshawar.
Material & Method: This descriptive cross sectional study was conducted in Pathology Department Hayatabad Medical Complex Hospital, Peshawar. Duration of the present study was, from January 2014 to December 2016. A total number of 605 children were enrolled up to 18 years of age, who suspected to have leukemia went through bone marrow examination by different department clinicians. 3 ml blood was collected in EDTA tube (purple top) and complete blood count was performed by hematology analyzer (Ruby cell dyne, Abbott, USA). By aseptic techniques bone marrow aspiration and bone marrow trephine biopsy samples were collected from all patients. Slides were papered from bone marrow aspirates, fixed with methanol and stained with Giemsa, myeloperoxidase and periodic acid Schiff stain. Trephine biopsy slides were stained with hematoxylene & eosin and reticulin stain. Immunohistochemistry was done after initially seeing of bone marrow aspirate slides. All data was documented and statistical analysis was performed by SPSS-20 software.
Results: Among 605 children, 173 (61.6%) were males and 108 (38.4) were females and their age range from 3 months to 18 years with median age of 9.8 years. In total children 281 (46.5%) were diagnosed different type of leukemias. Out of 281 cases, 208 (74.03%) were diagnosed to have acute lymphoblastic leukemia and rest of the children were 61 (21.70%) acute myeloid leukemia, 7 (2.49%) chronic myeloid leukemia, 3 (1.07%) had juvenile chronic myelomonocytic leukemia (JCMML).
Conclusion: In the present study acute lymphoblastic leukemia were more prevalent leukemia in the children of Khyber Pakhtunkhwa and Afghanistan. Juvenile chronic myelomonocytic leukemia was found less commonest leukemia in the present study.