Hematology

Biography

Biography: Lucia Stančiaková

Abstract

Antithrombin is a representative of the natural anticoagulants. It is an inhibitor of thrombin and activated forms of coagulation factors IX, X, XI, XII, kalikrein and plasmin. Deficiency of antithrombin represents 3-7-fold increased risk of the venous thromboembolism in the comparison with other thrombophilic states. This clinical finding may be inherited or acquired. Heritable antithrombin deficiency is a rare thrombophilia inherited in autosomal dominant manner.The authors aim to present a clinical case reports of patients with challenging management of repeated thrombotic complications and antithrombin deficiency. In the discussed patients, repeated thrombotic complications were developed. Additionally, the authors discuss etiopathogenesis, diagnosis and treatment possibilities of this thrombophilic state. Antithrombin deficiency is a high-risk thrombophilia and a rare clinical state. Despite full anticoagulation, repeated thrombosis may occur and can have severe clinical consequences. Therefore, close monitoring of the affected patients is inevitable.This study complies with the Declaration of Helsinki and informed consent of the patient included in the study was obtained.

Acknowledgement: Authors thank the support of the projects of the Scientific Grant Agency Vega 1/0549/19 and the Agency for the Support of Research and Development APVV-16-0020